There are several natural supplements that are commonly used for skin whitening, although their effectiveness and safety can vary.  
 
Glutathione: Glutathione is a powerful antioxidant that is naturally produced by the body and is believed to play a role in skin health. Some studies suggest that taking glutathione supplements orally or through intravenous injection may help lighten the skin and reduce the appearance of hyperpigmentation. Produced by our body, those seeking skin whitening effects need more quantity, a bit little (in the opposite way) those seeking to fight against light deprecion need more vitamin D that is not in enough quantity in the food eaten.

Vitamin C: Vitamin C, also known as ascorbic acid, is another potent antioxidant that is essential for skin health and collagen production. It is commonly found in citrus fruits, berries, and leafy green vegetables, and is also available in supplement form. Some research suggests that vitamin C may help lighten the skin and reduce the appearance of dark spots and hyperpigmentation when applied topically or taken orally. The very role of vitamin C is to spread the effect of glutathione that itself would have no real effects.

In skin whitening injections the average recommended dosage (for those who have a phototype above IV level) is 1200mg of glutathione associate with an injection of 500mg of vitamin C.

Vitamin E: Vitamin E is a fat-soluble antioxidant that helps protect the skin from damage caused by free radicals and UV radiation. It is found in nuts, seeds, and vegetable oils, and is also available in supplement form. While there is limited evidence to support the use of vitamin E supplements for skin whitening, some studies suggest that it may help improve overall skin tone and texture. The effect for skin whitening is limited but it is useful in general.

Alpha-arbutin is a natural derivative of hydroquinone, a commonly used skin-lightening agent. It is derived from the bearberry plant and is believed to inhibit melanin production in the skin, leading to a lighter complexion. Alpha-arbutin is often found in skincare products and supplements marketed for skin whitening.

In some skin whitening tablets, it is often associated with glutathione and vitamin C. Other skin whitening plans, made of tablets or injections, contain a more diverse range of antioxydant to fight free radicals, have melanin inhibators, skin detoxifications etc.

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